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Meet Nick Thune, who looks like he lives in Portland. But no, he's an LA guy (Silverlake wishes they were Portland, but are too vain to let go of that false sense of Hollywood importance). Thune's done work with Mr. Show and appeared in Knocked Up amongst others. For more on the up and coming comic, check out this Onion AV Club interview. But I suppose what really matters at this point are the jokes—not the history.
(NSFW) Masturbation Story:
A bit of standup. Don't worry, Thune doesn't sing funny songs. He uses the guitar for backing music a la Zach Galifianakis' piano (holy crap—I spelled Galifianakis right the first time):