Helium is opening in SE Portland towards the end of July, and they just launched a website, complete with a schedule for first few weeks. And right off the bat they've got a few shows to be excited about, including:

Natasha Leggero (August 5th-7th)
Maria Bamford (August 12th-14th)
Bill Burr (Aug. 19th-21st)
Christian Finnegan (September 16th-18th)